- Cool Tool – The Human Protein AtlasPosted 6 days ago
- Optimization of Roche Liberase MNP-S GMP Grade in the Enzymatic Digestion of Human Umbilical Cord for the Isolation of Mesenchymal Stem CellsPosted 7 days ago
- Ask the Expert – Maximizing Transient Protein ProductionPosted 1 week ago
- Enabling Viral Vector Production and Vaccine Manufacturing using the iCELLis – a single-use, automated, and closed manufacturing platformPosted 2 weeks ago
- Cell Culture Basics – Mycoplasma 101 – A practical guide to prevention, detection and elimination of mycoplasma contaminationPosted 3 weeks ago
- Going to BPI West 2017? Don’t miss these great talks and activities!Posted 4 weeks ago
- Cool Tool – PRIME-XV® T Cell CDM – First Commercially Available Chemically-defined, Animal-component-free Medium for T Cell CulturePosted 4 weeks ago
- Increasing Protein Production with Novel Cell-Ess Titer Boost without Affecting the Metabolic ProfilePosted 1 month ago
- Continuous Processing Optimization with Smarter ToolsPosted 1 month ago
- Cool Tool – Generation of Neural Stem Cells from AlphaSTEM Cultured Pluripotent Stem CellsPosted 1 month ago
The future of cell culture development? Part I
As we learn more and more about the detailed workings of cells used in biomanufacturing, methods to modify these workings are developed. This recent article from GEN describes some technologies that were unavailable to cell culture scientists in the past; glycoengineering and site-specific integration.
The sequencing of the CHO genome should provide even more opportunities to improve biopharmaceutical production. Several groups have sequenced CHO cell lines; GT Life Sciences collaborated with BGI to sequence CHO-K1 [announcement pdf], while Selexis collaborated with several Swiss institutions to sequence their proprietary “SURECHO-M” line.
These are just a few examples of techniques that can be used to develop cell lines to produce biopharmaceuticals. It should be interesting to see how regulatory agencies treat drug applications that use cell lines that were developed using advanced techniques such as these.