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Enhancers for monoclonal antibodies and recombinant protein production.
As described by Allen et al. several enhancers for mAbs and recombinant proteins are available and they have been tested. I tried these enhancers and I got results cell line-dependents. I would like an insight on other possible enhancers with great care to monoclonal antibodies.
Allen MJ, Boyce JP, Trentalange MT, Treiber DL, Rasmussen B, Tillotson B,
Davis R, Reddy P. Identification of novel small molecule enhancers of protein
production by cultured mammalian cells. Biotechnol Bioeng. 2008 Aug
15;100(6):1193-204. doi: 10.1002/bit.21839. PubMed PMID: 18351681.