Are there any vaccine targets that you would not want to manufacture using single-use systems maybe a highly infectious/toxic target or some other factor? Are there any special conditions that should be considered?
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Single-Use Technology for Microbial Fermentation
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Application of single-use technology does not relieve the process owner from assessing any and all appropriate risks. The infectiousness or toxicity of a process, process intermediate or end-product should be considered, with operator safety being paramount. Unlike stainless steel fermentors, single-use fermentors rely on plastic films, tubing, etc. There are risks, though low, of breaches in the integrity of the film or tubing or failures due to miss use.
This post is sponsored by Cytiva (formerly GE).