Ph.D. Sigma Mostafa

Sigma has nearly 20 years of experience in process development, process characterization and validation, and manufacturing of therapeutic proteins. At KBI, she is in charge of the cell line, upstream, downstream, and analytical development groups that support development of 40 – 50 molecules per year. These molecules encompass all phases of development and represent mAbs, bi-specifics & fusion proteins, enzymes, vaccines, and complex glycoproteins. Prior to joining KBI in 2010, she was with Eli Lilly & Co. and Diosynth Biotechnology. At Lilly she led a process development group and also the high throughput cell line selection group and was a CMC Core Team Leader. At Diosynth she was manager of the Cell Culture group and was responsible for developing in-house (Merck) and client processes. Sigma’s core expertise are in phase I through commercial process development, scale-up/scale-down, and tech transfer. Sigma earned her Ph.D. in Chemical Engineering from Northwestern University. She completed her B.S. in Chemical Engineering from the University of Texas at Austin with High Honors

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