Can you tell me whether there would be cost benefit from switching to single-use technology in microbial fermentation and if so, from where?

Answer

Equipment utilization will be much greater due to the faster turnover between runs. Single-use avoids post-run CIP, cleanliness validation, sterilization and pressure testing. The risk of cross-contamination is virtually eliminated. The consumption of water in CIP and sterilization is tremendous. Maintenance is almost non-existent by comparison; with no seals, O-rings or gaskets to replace between runs; not mechanical seals service, etc.