What kind of target types using electroporation, i.e. non-antibody proteins, antibody fragments, fusion proteins?


Electroporation can be used to engineer cells to express a range of proteins from secreted proteins, membrane proteins or cytosolic proteins. In terms of protein biotherapeutics, MaxCyte clients have expressed recombinant antigens, full IgGs from multiple species, bi- and tri-specific antibody, FcSv, Fab and Fc, or other fusion proteins. One benefit of electroporation over other transfection technologies is the ability to easily control the ratio of plasmids during cotransfection, a property particularly useful for multi-subunit proteins. MaxCyte systems are the only FDA approved instruments and thus can produce cGMP grade materials which can be used for toxicology and clinical studies.

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