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There are commercially available serum free media suitable for the optimization of recombinant blood factor expression in CHO or BHK cells. Depending on the cell type and specific molecule of interest, the media may need to be supplemented with other components (e.g., growth factors, cell protection agents, and product dependent factors). Media optimization should always be performed in conjunction with process optimization (e.g. fed-batch vs. perfusion, tuning of process parameters) to achieve optimal outcomes.