Efficient mixing in bioreactors is important when adding bases or acids to control cell culture pH or when adding nutrients to the cell culture. Advanced impeller designs and improved process understanding have reduced the impact of shear on cells. Currently mixing topics are focused on the dissolution of oxygen and the stripping of CO2 and reduction of the concentration gradient. To better understand the factors involved in successful bioreactor mixing, please see the video below titled, “The Impact of Mixing on Cell Culture in Bioreactors.”
The Keck Graduate Institute and WuXi Biologics have teamed together to provide technical training videos called Two Minute Tuesday videos for the bioprocessing industry. They will deliver a new video topic every Tuesday that can quickly get you up-to-speed in understanding the complexities of biologics drug development and manufacturing.