This article was originally published in the eBook
“What’s In Your Media”.
Cell culture media remains a key component of biologics-based therapeutics manufacturing. As such, cell culture media development and optimization continue to be important focuses for the biopharmaceutical industry. Increased analytics capabilities have provided new insights into the relationship between cell culture media, the cells they support, and ultimately, the outcome of the final biologics product. That greater insight offers more opportunities to create products faster, more cost effectively, and with greater therapeutic success.
Media development and optimization are critical when looking to streamline biotherapeutic process development. Analyzing how cells consume medium components provides valuable information about the health and productivity of the overall production process. Analysis of key media components — such as amino acids, vitamins, and the metabolites produced as a result of cell growth — is beneficial at all stages of process development, including cell line development, media development, and process optimization. This information provides insight not just on media composition and performance, but also on clone selection, optimal harvest time, potential product quality issues, purification strategies, and more.
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