I am curious, we are getting good productivity in our glass benchtop bioreactors, but when we scale up to 200 liters, our productivity drops. We have seen that this is due to a decrease in vcd. What could you recommend we try?
This question is part of the following Ask The Expert session:
How to Improve Protein Productivity Through Scale Up, Including Single-Use Bioreactors
Answered by:
Answer
We have seen similar results in glass, steel, and SUBs with Cell-Ess. I have several questions and maybe we can go through them together offline. For example what does your VCD curve look like in each vessel? Do you know what may account for the different curve shapes? There are several other questions we can go through. Please feel free to use Essential as a resource.
This post is sponsored by Essential Pharmaceuticals, LLC.