If I understand the application correctly, it seems to be primarily in the research field, not in actual Cell Therapy use. If so, what is the advantage of serum-free over using serum in the culture if it is for research only?

Answer

As with all therapeutics, primary research is essential to ensure any procedure is safe and effective as a treatment. Experiments have already been performed demonstrating the feasibility of re-integration of intestinal cells in mice (1). This serves as a proof-of-concept for future, more advanced treatments requiring that the culture medium is serum-free and defined. The use of serum in media also introduces an additional level of variability that most researchers find undesirable.

(1) Yui S, et al. Nat Med 18: 618-623, 2012