It seems that single-use is a good option for new processes, but for existing processes what points would you consider when deciding whether to change to single-use?

Answer

Single-use technology is a good option for new and existing processes. There may be more to evaluate for existing processes because is it already operational. Consider that single-use technology shortens the turnaround time thereby, effectively, increasing equipment utilization. The industry remains very competitive and saving time had direct benefit to the bottom line. Also consider the amount of time and, if nothing else, the water associated with cleaning a fermentor between runs. Water is a valuable resource with daily headlines trumpeting its scarcity. Consider, too, footprint…and not just the footprint at the fermentor. Single-use fermentors do no rely on piping skid adjacent to the vessel; nor do they require clean or plant steam sources.