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A spheroid can be a mere aggregate of one or more cell types where cells do not attach to a surface other than to other cells to form a spheroid. Ultra low attachment spheroid microplates are an ideal tool to form and assay spheroids in the same microplate. Organoids, on the other hand, differentiate and self-organize to form 3D structures that resemble and at least partially function like the organ they resemble. They require attachment to extracellular matrix like Corning® Matrigel® matrix or Collagen-I and specific developmental signals to organize into organoids.