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Wow this a good question. With the latest technology there are many ways to measure cell health and other things that will ultimately make cell culture production better. For example Molecular Probes makes some great fluorescent dyes for just those purposes. pHrodo Indicators for example get onto cells and change colors depending on the cytosolic pH. Conjugates with pHrodo allow for visualization of ligand or antibody internalization. Also chemicals such as AlamarBlue or Live/Dead cell viability assays allow for easy detection of proliferation which is related to improvements in a cell culture process.