I am not very familiar with culturing on chips. How does this work compare to regular culture?

Answer

When working with more complex organoid models, there are many important factors to consider including the extracellular matrix, fluid transportation, controlled medium exchange and spatial separation. For these more advanced models, the combined usage of extracellular matrices with a “organ on a chip” method may prove useful.  The chip serves as a “scaffold” which can be used to create compartments.

Please find here a few examples of organoids cultured on a chip: