Is it true that intestinal organoids can be used for personalized medicine for treating intestinal disease? Is this only in the research stage or have clinical trials been done?

Answer

Intestinal crypts can be isolated from a patient, grown into organoids, and subjected to preclinical drug screening to determine the optimal treatment for that individual. Currently, The HUB Foundation for Organoid Technology is generating a library of human organoids, or “biobank”, derived from healthy and diseased tissue for the purposes of preclinical drug screening. Note that IntestiCult™ Organoid Growth Medium (Mouse) is for research use only, and for establishing mouse intestinal organoids.