Have you used the new poloxamer to protect against shear when using microcarriers in vaccine production?

Answer

We have developed our new Poloxamer 188 EMPROVE® EXPERT to achieve reliable quality and consistency providing shear stress protection for large scale cell culture processes in biopharmaceutical productions. We have mainly worked together with mAb manufacturers and performed several tests to identify correlations between physical and chemical properties and cell culture performance. It has been decided to implement a cell based assay with different CHO cells with well-characterized shear sensitivity to assess and classify the shear protective effect. First vaccine manufacturers are currently testing our new product and we are curious to see the results. But so far the new poloxamer has not yet been used in vaccine production.