Silver Sponsor
MilliporeSigma
MilliporeSigma, a life science leader, is a business of Merck KGaA, Darmstadt, Germany. We offer products to safely and efficiently develop and manufacture therapeutics. Our products and services include single-use manufacturing, filtration, chromatography and purification, virus reduction, pharma and bio-pharma raw materials, drug delivery compounds, validation services and biopharmaceutical training. With the acquisition of Sigma-Aldrich, we now have the largest offering of products and services for formulations, actives and biotechnology processes.
Associated Experts
Job Title: Head of Laboratory Functional Chemistry
Job Title: Global Product Manager
Job Title: Vice President, End-to-End Processing Solutions within Process Solutions
Associated Content
Viral Vector Process Intensification: Stepwise Model for Efficient Scale-up
The unprecedented clinical success of novel cell and gene therapies (CGT), such as CAR-T cell therapy, has led researchers to shift to treating conditions more prevalent in the general population. This has resulted in growing market demand for the viral vectors used in these therapies. The global viral vector manufacturing market is expected to reach $2.2 billion by 2027....Continued
GMP-Compliant Benzonase® endonuclease Safety Plus Emprove® Expert Provides Enhanced Risk Mitigation
Benzonase® endonuclease has been used in biopharmaceutical production for DNA removal for over 30 years. It is a genetically engineered endonuclease, from Serratia marcescens, which can completely hydrolyze all forms of DNA and RNA (single-stranded, ... Continued
Efficient DNA Clearance Enables Better, Faster Virus Production
Viruses are essential raw materials used to genetically modify cells for viral vaccines or as viral vectors for gene therapy manufacturing. For intracellular viruses, the host cells used to manufacture virus particles must be lysed ... Continued
Cool Tool: Fit-for-purpose Cell Therapy Bioprocessing Platform – MilliporeSigma ekko™ System
Cell and gene therapies require innovative processing technologies to meet the demands of moving from research into clinical and commercial manufacturing. Technologies must be designed to increase safety, efficiency and provide cost effective solution. The ... Continued
Non-Animal Origin cell culture supplements and manufacturing aids for biologics manufacturing
In this podcast, we talked with Dr. Tobias Hertzig, Regulatory Affairs Manager and Dr. Ulrich Tillmann, Global Product Manager, Supplements and Manufacturing Aids both representing Merck KGaA, Darmstadt, Germany. We discussed non-animal origin cell culture ... Continued
Optimizing Fed Batch Culture – Developing New Tools and Methods to Improve Production
In this podcast and accompanying article, we interviewed Dr. Aline Zimmer, Head of R&D, Advanced Cell Culture Technologies at Merck about the importance of optimizing fed batch cell culture for successful biomanufacturing. Aline discussed how ... Continued
Chemically modified amino acids enable the evolution of fed-batch processes from multiple feeds to single feed strategies
Cell culture optimization is critical to good biomanufacturing. In particular fed-batch cultures require optimization of feed strategies to ensure that cultures are not becoming nutrient depleted, to extend the growth phase and increase product concentration. ... Continued
New chemical modification of L-Tyrosine and L-Cysteine increase solubility and stability and permit single feed strategies
A long-standing challenge in the use of amino acids as part of a feed strategy has been the insolubility of tyrosine and the oxidation of cysteine at neutral pH. This has required the use of ... Continued
Addressing Shear Stress in Bioreactors
Introduction Introduction of oxygen to cell culture media via sparging is critical for efficient bioreactor operation. Since oxygen is sparingly soluble in culture media, efficient sparging methods are important to ensure cells have enough oxygen for ... Continued