We are looking for a synthetic surface for our iPSCs. Do you have any suggestions and what should we look for when evaluating?


The most commonly used and commercially available synthetic substrate is Synthemax by Corning. This substrate has been used along with Essential 8 medium by many scientists. These are the following evaluations:

1. Test for pluripotency after culturing cells for a long period of time (50 passages or more).

2. Test for the ability to form Embryoid Bodies and potential for tri-lineage differentiation

3. Test for normal karyotype after long-term use of Synthemax

4. Test for the ability of the cells to differentiate into the cells of your interest

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