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Cell-Ess is can be both a supplement and a feed. The nomenclature for the manufacturing process can be a little confusing. For example, supplements can be used as feeds. What we found is that each clone is different, and the media requirement may be slightly different. Therefore, optimization is the key. In some cases, Cell-Ess is best as a one-time use at time zero. Other times Cell-Ess is best used as 2 or even 3 feeds. The important thing is that once an optimal point is reached, then it stays the same, and the reproducibility is observed for run after run.