Don’t miss our top Cool Tools of 2019! I have compiled a list of our most popular 10 Cool Tools for 2019 in alphabetical order.

Advanced Bioprocess Controller Puts Cell Culture on Autopilot

Bioprocess controllers are an important part of a bioprocess lab. In many bioprocess labs several experiments are running simultaneously sometimes using multiple cell types with different modes and at varying scale. A bioprocess controller can help to simplify these demands, provided that the controller isn’t overly complex or challenging to operate. The goal is finding a bioprocess controller that permits maximum flexibility while still being straightforward and simple to use…

Eliminate Contamination and Improve Efficiency with Gibco™ One Shot FBS

Fetal bovine serum is a widely used cell culture media supplement for the successful in vitro culture of many cell types. FBS is a rich source of nutrients, hormones, lipids, adhesion factors in addition to acting as carriers for growth factors and supplying buffering capacity to the culture media. FBS is commercially available from many manufacturers, and because the composition of FBS is variable in its ability to support cell proliferation, customers may need to test specific batches for suitability for their specific cell type. FBS is stored at -20°C to preserve the stability of the components in serum, such as growth factors, thus the inventory management and storage of FBS can sometimes be a daunting and time-consuming task particularly where many cell types are being cultured…

Innovative Improvements Increase Productivity and Throughput for Next Generation Cell Viability Analyzer

Increasing the productivity and throughput of all aspects of bioprocessing has been a key goal for most research and biomanufacturing operations. As a result more and more steps in both upstream and downstream processing are being examined to see where improvements can be made…

Launch of IncuCyte SX1 Model Expands Live-Cell Analysis Accessibility and Options

Cell models and cell systems have continued to evolve to meet research and drug discovery demands. Researchers are looking to increase physiological relevance of their cell models to ensure potential therapeutics have a higher chance of being both efficacious and safe. This desire has prompted many researchers to move from simpler recombinant cell systems to complex primary cell or stem-cell derived cell-based models. Co-cultures, multi-cultures and tissue organoid models offer significant promise, but also pose a greater challenge than the typical cell culture workflow. In addition, these cells and cell models tend to be more sensitive to minor deviations in their culture environment and as a result often have specialized requirements…

New BenchStable™ Media Provides Flexibility and Convenience While Helping the Planet

Researchers looking for reduced cold storage space requirements and easier access to media on their bench top, now have an answer. Recently launched Gibco™ BenchStable™ media are specifically engineered for room-temperature storage. This permits flexible media storage on the lab bench, thus freeing up valuable cold storage space…

New chemical modification of L-Tyrosine and L-Cysteine increase solubility and stability and permit single feed strategies

A long-standing challenge in the use of amino acids as part of a feed strategy has been the insolubility of tyrosine and the oxidation of cysteine at neutral pH. This has required the use of alkaline feeds to allow solubility and stability. The need for alkaline feeds complicates operations by forcing a multiple feed strategy as all components can’t be fed together…

Novel Acoustic Platform Provides Gentler, More Efficient Solution for Cell Processing

Cell and gene therapies are in need of evolving manufacturing technologies to move products from research, through development and into, commercial manufacturing. As more cell and gene therapy products achieve clinical success, more investments are being made in creating manufacturing technologies to support the industry. There are several advancements in this area including the closing and automating of many manufacturing processes and increasing efficiencies with the creation of fit for purpose equipment and consumables. There are still, however, many needed improvements to further increase productivity and reduce cost…

PEIpro® enables seamless scale-up of transient transfection for therapeutic viral vector manufacturing

During process development (PD) for virus vector production, choosing raw materials from reliable suppliers that can provide the highest quality to meet Advanced Therapy Medicinal Products (ATMP) GMP guidelines is key and will facilitate transition to large-scale clinical-grade virus manufacturing. With the launch of commercially available PEIpro^®-GMP, Polyplus-transfection® SA now provides a complete PEIpro® product range to address concerns often raised with transient transfection for large scale manufacturing of viral vectors: efficiency, reproducibility and scalability…

Quantitative LC-MS Solution for Targeted Analysis of Cell Culture Media

Cell culture media optimization is a critical aspect of process development. To ensure the best manufacturing productivity and final product quality, media components must be carefully evaluated. In the last decade, the biopharmaceutical industry has developed a greater understanding of individual medium components and their profound impact, not just on how much titer can be achieved, but also on the quality and efficacy of the final product. In order to better understand how each of these components affects critical quality attributes, it is important to conduct a thorough cell culture media analysis…

Vivaflow Crossflow Cassettes provide plug and play target molecule concentration systems that are scalable for a wide range of sample volumes

Ultrafiltration is an important function in many labs. While there are many ways to conduct concentration and filtration, it is critical that you select the appropriate method for target recovery and sample volume, while still considering speed and efficiency. Sartorius has launched its Vivaflow Crossflow Cassettes with these requirements in mind. With three products specifically designed to meet different customer requirements, they provide a simple to use, plug and play system for concentrating a wide range of sample types, over volumes from 0.1 liter to 5 liters, with high reliability and consistency of results…