Platinum Sponsor
Invitria
InVitria products allow users to eliminate animal components from their cell-based processes. Removing these components helps improve consistency, safety and efficiency. InVitria’s products are recombinant proteins that are manufactured using cGMP standards in our manufacturing facility in Junction City, Kansas. These products have many uses across the life science industry including in regenerative medicine, cellular therapy, biomanufacturing, vaccines, diagnostics and medical devices.
Associated Experts
Job Title: Media Formulation and Product Applications Specialist
Job Title: Technical Applications Specialist
Job Title: Technical Applications and Marketing Associate
Job Title: Cell Culture Scientist
Job Title: Cell Culture Scientist
Associated Content
Publication review: Formulation and production of a blood‐free and chemically defined virus production media for Vero cells
The data presented demonstrates that OptiVERO performs as well as (or better than) FBS-containing media in cell proliferation and virus production and also outperforms the plant hydrolysate-containing VP-SFM media....Continued
Recombinant Human Serum Albumin Excipient – Regulatory Filing and Approval for Use in Vaccine Manufacturing
During the 2020 Excipient World Conference & Expo, supported by IPEC-Americas, Kara Quinn, the Associate Director of Engineering for Merck & Co, presented a webinar detailing the first-hand account of the complex process of regulatory ... Continued
Enhancement of transient transfection with serum-free and blood-free transferrin
Regardless of the mechanism, a serum-free, blood-free, recombinant human transferrin is able to achieve high transfection efficiency, and high viral titer, suggesting that blood-free transferrin has high functionality in a chemically-defined medium....Continued
Optimized Chemically Defined HEK293t Media for Viral Vector Production Provides High Performance, Consistency and Safety
Efficient viral vector production is a key element for gene therapy manufacturing. To ensure the best production, special care must be taken when selecting a cell culture media formulation. Ideally, media should provide high productivity, ... Continued
Expansion of Mesenchymal Stem Cells in Blood-free, Chemically Defined Media
Last month’s ISCT conference held in Montreal, Canada featured many novel approaches for cell therapy research and manufacturing. One of the posters presented at the conference, “Inclusion of Recombinant Albumin and Transferrin Enables the Blood-Free ... Continued
Benefits of a defined, blood-free virus production media for vero cells
Vero cells are a very popular cell line choice for virus production in vaccine manufacturing. Reasons for their popularity include a long history of safety and successful proliferation in variety of vessel types including flasks, ... Continued
Optimizing Virus Production Media for Cell-based Vaccine manufacturing
Cell-based Vaccine Manufacturing There has been increasing interest in moving from egg-based vaccine manufacturing to cell culture-based methods. Cell-based vaccine manufacturing is quicker, efficiently scalable and offers more control over the manufacturing environment. There is also ... Continued
Incorporating recombinant proteins to produce blood-free media formulations for therapeutic cell types
Introduction Inclusion of human plasma or plasma-derived proteins, such as albumin and transferrin, in cell culture systems produce media with acceptable performance at small scale. However, scale up to clinical manufacturing with these components proves to ... Continued
Xeno-Free, what is it?
Cells are complex and intricate microscopic wonders that are now being recognized as having infinite potential as therapeutic agents to fight against devastating human disease. The Cell Therapy space is now rapidly growing in the ... Continued
Optimizing Vero Cell Culture Media with Animal Component-free, Recombinant Human Serum Albumin
Introduction Vero cells are a monkey kidney cell line that has been a relative constant in the vaccine industry for over 3 decades. These cells have a long and successful history of safe vaccine production for ... Continued
Optimizing T cell media with animal component free, recombinant human serum albumin
Introduction There are an increasing number of T cell-based therapeutics moving through clinical trials. These immunotherapies hold tremendous promise and much of the clinical trial data has been impressive. As these therapies have progressed toward larger ... Continued
Mitigating Risk beyond Xeno-Free: Virus Stabilization during Culture and Final Formulation
Previously, we demonstrated the critical importance of the animal component free recombinant human serum albumin product Cellastim in the expansion of cells relevant in virus production for vaccines using cell lines VERO and MRC-5. The ... Continued
Mitigating Risk beyond Xeno-Free: A Critical Component for Cell-Based Vaccines
It is a common misconception that the cost of recombinant versions of critical proteins like human serum albumin is too high to be incorporated into large scale cell culture for vaccine production and other applications. With InVitria's animal component free, recombinant HSA (Cellastim), the incorporation of a recombinant human albumin can be affordable and eliminate key disadvantages of working with an unpredictable product like human blood derived serum....Continued
Zap-SR; Reduced Serum Conditions for Industry Relevant VERO Cell Expansion
In our last article, “Zap-SR Utility in Expanding Cells Critical in Virus Production”, we showed the efficacy of Zap-SR in propagating VERO cells in 6-well plates with an 80% reduction in FBS. While this data is significant, it prompted further investigation of additional cell lines and culture vessels to allow for a better understanding of the impact of Zap-SR on reducing serum in cells relevant for virus production....Continued
Zap-SR Utility in Expanding Cells Critical in Virus Production
This proliferation data hints at the utility of Zap-SR in expanding cells that are relevant in vaccine and therapeutic virus production in reduced serum conditions. The incorporation of Zap-SR allows conservation of the dwindling serum supply and simultaneously creates cost savings for the end-user. In addition, these encouraging results prompt the further investigation of Zap-SR efficacy in expanding Vero cells in more relevant culture systems such as spinner culture in addition to testing Zap-SR in other cell lines that are commonly used in virus production....Continued
Hybridoma cell growth and performance in reduced serum + Zap-SR
It is well known that serum and other animal derived components can create inconsistency in cell culture, leading to variability in growth and performance. In order to reduce the amount of serum required, as well ... Continued
Optimization of serum free media for the propagation of primary and stem cells in animal and human serum component free conditions
Introduction Optimization of serum free media can be a complex and daunting challenge for scientists working to bring a cellular therapy to market. When considering raw material sourcing, it is important to limit animal or human ... Continued
Cell Culture Media Optimization: Making the perfect magical potion
As you can see, there is absolutely nothing magical about serum free media. By starting with high quality, economical, animal free proteins such as Cellastim and Optiferrin , a high performance regulatory-friendly stem cell media is achievable. No fairy dust, hocus pocus, or unicorns needed....Continued
Defined, Animal-free Virus Production Media
In our previous blog “The Evolution of Vaccine Manufacturing – Past, Current, and Future Trends,” we discussed the importance of continued innovation in vaccine manufacturing. These innovations are critical to reducing manufacturing costs and improving ... Continued
Robust, Defined, Animal-Free Virus Production Medium Optimized for Microcarrier Culture
Steve Pettit, Grishma Patel, Mark Szczypka, Claire Y.-H Huang, Bart Tarbet Abstract: The use of undefined components in animal product-free (APF) cell culture media could cause inconsistencies in cell growth and viral production. InVitria has developed a ... Continued
Expansion of therapeutic stem cells
Introduction The full realization of the therapeutic potential of stem cells has only recently come into the forefront of regenerative medicine. Promising in vivo results have fueled the enthusiasm among basic researchers and their clinical colleagues ... Continued
Planting the seed: plant-based biologics for the expansion of therapeutic stem cells
The full realization of the therapeutic potential of stem cells has only recently come into the forefront of regenerative medicine. Promising in vivo results have fueled the enthusiasm among basic researchers and their clinical colleagues ... Continued
Quality vs. Cost in Biopharmaceutical Manufacturing – Ways to Acheive Both
A major topic of discussion at Biomanufacturing Summit 2012 was the concept of cost versus quality. A striking trend of an increasing number of quality problems and subsequent increase in warning letters has appeared over ... Continued
The Importance of Culturing Human Embryonic Stem Cells in Animal-Free Conditions
Human embryonic stem cells (hES) due to their ability to differentiate into all cell types offer great promise for clinical cell based therapies. The majority of hES cell lines available to date have been directly ... Continued