Eppendorf SE

Associated Content

Production of MSC-Derived Exosomes Using Bioreactor Systems and Controllers

Mesenchymal stem cells (MSCs) have been at the epicenter of regenerative medicine since their identification in the 1970s, due to their ability to differentiate into various mesoderm-derived cell types, their immunomodulatory function through paracrine factors ... Continued

Advancements in Cell and Gene Therapy Stirred-Tank Bioreactor Suspension Culture

In this podcast, we talked with Dr. Ma Sha, Head of Bioprocess Applications at Eppendorf SE about advancements and challenges in cell and gene therapy production along with solutions for scale up and transition to ... Continued

How Stirred Tank Bioreactors and Bioprocess Controllers can Enable Efficient Automation and Scale-Up to Streamline Bioprocess Optimization

For decades, the biopharmaceutical industry has relied on mammalian cells, particularly Chinese Hamster Ovary (CHO) cells, to produce therapeutic proteins, which requires the establishment of robust and scalable manufacturing processes. Development typically starts in the ... Continued

Improving Upstream Bioprocessing Efficiency with Digital Tools

Digitalization holds great promise for increasing the efficiency, quality, and reproducibility of upstream bioprocessing. From automating a bioprocess run, process optimization through modeling and statistical methods, digital solutions for equipment maintenance, and cloud-based data handling, ... Continued

The Reproducibility Challenge in Bioprocessing

Achieving bioprocess reproducibility in cell culture-based production environments that are inherently variable can be frustrating for biomanufacturers. Not only that, it also contributes to increased batch costs, overall process inefficiencies and extended timelines. As an ... Continued

Bioprocessing Solutions to Accelerate Mammalian Cell-Based Vaccine Development

Vaccination remains one of the most effective methods to combat infectious viral diseases such as influenza. The recent COVID-19 crisis has placed unprecedented pressure on the vaccine industry to develop and deploy vaccines against emergent ... Continued

Examining Bioprocessing Scale-Up Challenges and Technology Solutions

The number of novel cell and gene therapeutics gaining regulatory approval is on the rise to treat a variety of human diseases. Yet, these complex biologics-based therapies present challenges for drug companies as to the ... Continued

DASbox Mini Bioreactor System’s small working volumes and advanced control options offer a versatile solution for advanced process development experiments

The DASbox was designed to enable parallel operation to streamline process development and DoE, while still offering the advanced controls found in industrial bioreactors....Continued

Successful Exosome Production Using Stem Cell Culture in Stirred Tank Bioreactors

In a recent study, Eppendorf used a combination of the SciVario® twin bioreactor control system and the BioBlu 1c single-use vessels as a model for large-scale exosome production in bioreactors....Continued

Next Generation Bioprocess Controller SciVario® Twin Provides Flexible Solution to Address Current and Future Needs

The SciVario twin was designed to control both small- and bench-scale bioreactors to enable efficient scale-up. Thus, enabling growth and adaptation as the process evolves. The system is equipped to handle future software updates and hardware extension releases, allowing the system to evolve with processes without requiring additional investments in new control systems....Continued

Keys to successful single-use bioreactor scale up – from small scale to pilot scale

Successful monoclonal antibody (mAb) manufacturing relies on good process development and reliable bioreactor scale up. Initial process development work is typically conducted at small scale, then moved to bench scale and lastly to pilot scale ... Continued

Advanced Bioprocess Controller Puts Cell Culture on Autopilot

Eppendorf is looking to make life easier for those working in bioprocessing labs by reducing training time and providing pre-set culture processes in the BioFlo® 120 bioprocess control station....Continued

Scalable Production of hiPSC-Derived Cardiomyocytes in Stirred-Tank Bioreactors

As part of our continuing conference coverage of the International Society of Cell & Gene Therapy 2018 held in Montreal, QC, we like to highlight interesting posters from the event. One such poster, “Scalable Production ... Continued

State of the Art CO₂ Incubators Offer Safe Haven for Sensitive Cells

Cell culture CO2 incubators are a critical part of the cell culture process as cells spend most of their time here. The CO2 incubator’s purpose is to create ideal living conditions for cells to thrive, ... Continued

A Defined Synthetic Growth Surface for Stable hiPSC Expansion

Introduction hiPSCs cultivation can be challenging with lot-to-lot coating variations, tedious preparation and increased contamination risk. In particular, biological coatings may negatively impact downstream applications due to the presence of undefined extracellular matrix (ECM) components and ... Continued