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When it comes to scaling-up your big idea, you need a supplier who is as comfortable in the production suite as in the lab. Corning brings together the broadest selection of vessels, surfaces, and media to create an end-to-end solution for scale-up of anchorage-dependent and suspension cells. Find out how we can help you increase productivity, lower risk, and get your scale-up right from the start.
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Dr. Himabindu Nandivada, Ph.D.
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Associated Content
Lab Essentials – Tips for making your cell culture work more efficient, productive, and easier
Cell culture is a critical function of many life science laboratories, but how often do we stop to think about the best practices that could make our job a bit easier or our time at ... Continued
Corning® Matrices and Cultureware Solutions for 3D Cell Culture
While traditional two-dimensional (2D) cell culture has been foundational for in vitro studies, researchers are finding that culturing cells in 3D can better replicate the in vivo microenvironment of tissues and organs, providing a more ... Continued
Revolutionizing the Standard of 3D Bioprinting with the Corning® Matribot® Bioprinter
The continued investment by the scientific community and the availability of innovative, breakthrough technologies like the Corning Matribot bioprinter will provide researchers with the tools needed to propel 3D bioprinting forward to realizing its tremendous potential to revolutionize modern medicine and healthcare....Continued
Closed and Aseptic Processes for Cell Therapy Manufacturing
In this article, we identify key strategies to help researchers successfully transition their cell therapies from the lab to commercial production. We detail the advantages of implementing closed systems as well as some of the key hurdles when transitioning from traditional bioprocesses....Continued
Amplifying Adenoviral Particles in the Corning HYPERStack Cell Culture Vessel
The focus of this study was to determine the efficacy of generating amplified virus using the unique Corning HYPER technology. Standard methodologies utilize traditional stacked vessels for virus generation. Utilizing the HYPERStack vessel, researchers can generate similar titers in a smaller spatial footprint saving both time and space. The results depicted here demonstrate that the experimental approach to generate adenovirus in the HYPERStack vessel led to similar titers but larger yields compared to a standard 2-layer stacked vessel....Continued
Selecting the Appropriate Scaling Strategy for Different Cell Therapy Applications
The key to increasing patient accessibility to meet market demand for cell therapies will be better, scalable manufacturing processes in conjunction with automation tools that drive down cost and time-to-treatment....Continued
Media Optimization for Cell Therapy Production
While media customization and optimization for cell therapy manufacturing can feel daunting, there are key considerations to focus on. Working with a company to help with this work can be very beneficial in that it provides vast experience across a range of products and capabilities that is difficult and costly to replicate using in-house resources. In addition, outsourcing media customization, frees valuable labor and capital resources that cell therapy developers can utilize for other aspects of the cell therapy commercialization process....Continued
3D Human Liver Spheroids: Moving Towards Meaningful In Vitro Assays
During the Society of Toxicology virtual meeting held between March 12–26, 2021, Corning® Development Associate Feng Li, Ph.D. gave an interesting presentation alongside Michael Johnson, Ph.D., CEO of Visikol, Inc., on the use and physiological relevance of 3D human liver spheroids to conduct in vitro hepatotoxicity assays and other applications....Continued
Implementing Adherent Cell Culture Technology for Cell Therapy Bioprocess
Several of the most promising candidates in the pipeline use mesenchymal stromal cells and pluripotent stem cells, both of which require an adherent substrate for native biological function. Thus, utilizing an adherent platform for production of these cell types provides several advantages, including shorter process development and optimization time, no need to adapt cells to suspension, and the ability to implement various surface modifications that promote the relevant biology....Continued
Make Time for Process Development in Cell Therapy Production
Fulfilling the promise of cell therapy requires that we effectively transition from proven research-scale to production-scale capable of generating safe and effective therapies to treat patients. Taking a thorough approach to process development, adhering to emerging best practices, leveraging proven technologies and the expertise and resources of preferred vendors can help ensure that large-scale production success can be achieved....Continued
Cell Therapies Offer A Bright Future for Patients
Cell therapies offer a tremendous opportunity to increase our medicinal arsenal, but there are manufacturing challenges and solutions are evolving. Suppliers are creating innovative, fit for purpose products to solve the unique challenges that cell therapy products present. In this publication, we will discuss current solutions and also future opportunities for improvement....Continued
Ask the Expert – Transfection Best Practices for AAV Gene Therapy
The majority of vectors used for gene therapies are currently generated using transient production systems, primarily due to convenience and speed of process. Manufacturing viral vectors via transfection is flexible and efficient and does not ... Continued
Ask the Expert – Using Disease Models at the Air Liquid Interface to Advance Respiratory Disease Studies
From asthma to COPD, ALI models have been critical in researching respiratory diseases. With the recent outbreak and severity of the COVID-19 virus, this technology is becoming even more critical in the race to understand and treat disease. With the popularity of these more complex models growing, we have assembled a team of experts to answer your questions on disease modeling using ALI tools and systems....Continued
New Lab Set Up – Best Practices for a Successful Start
In this podcast, we spoke with Dr. Ann Rossi Bilodeau, Senior Bioprocess Applications Scientist and Dr. Catherine Siler, Field Applications Scientist both with Corning Life Sciences, who shared insightful tips for setting up a new lab. We discussed how to create a lab plan, maximize lab space, stay within budget and timelines. They also shared their experience in implementing lab safety and training as part of the new lab launch....Continued
The Dos and Don’ts of Cryopreservation
Successful cryopreservation requires thoughtful consideration of several key items, including cryoprotective agent selection, contamination testing, storage vessels, and cooling rate....Continued
Scalable High Yield System for Mass Culture of Attachment-Dependent Cells
As increasing numbers of cell and gene therapies progress from research to clinical trials and on to commercialization, the need for efficient manufacture of high numbers of cells is critical. Many of the cells used ... Continued
A Look Towards the Future of 3D Cell Culture – A panel discussion
This article is the fourth in a series that was published in the eBook “3D Model Systems: Spheroids, Organoids and Tissue Models”. You can download all the articles in the series, by downloading the eBook. Introduction and Overview Debbie ... Continued
Bringing 3D models into a High Throughput Environment
Elizabeth Abraham, Ph.D. - Senior Product Manager, Corning Life Sciences Elizabeth has been employed at Corning Life Sciences (CLS) since 2008 and has held multiple senior roles in various functions including R&D, Project Management and Business ... Continued
Organoid Models: Getting Started and Culture Tips
While this area of 3D models is relatively new, organoids have emerged as a powerful tool to complement existing animal and cell line models offering unprecedented insight into human development and disease. This opens up innovative approaches to medical research, drug discovery, toxicology testing and for advancing precision and regenerative medicine bearing great promise for the future....Continued
How to minimize contamination risk and protect your cultures
Dr. Elisabetta Difilippo is Scientific Supporting Specialist supporting EMEA regions at Corning Life Sciences. She assists in inquiries regarding products and applications of Corning Life Sciences portfolio, and she conducts scientific trainings. Dr. Difilippo graduated in ... Continued
Spheroid Models: Getting Started and Culture Tips
Undoubtedly, 3D spheroid cultures are an important addition to the research toolbox with huge translational potential, particularly for cancer and stem cell research. Their physiological relevance and the predictive nature of spheroids is helping to bridge the gap between in vitro and in vivo models, helping to drive novel discoveries and innovation....Continued
3D Model Systems: Spheroids, Organoid and Tissue Model Systems
This platform has the potential to decrease cost, replace animal testing and streamline drug discovery workflows to identify drug candidates that are safe and efficacious in humans....Continued
Using Organoids for Disease Modeling
The culture of organoids has permitted researchers access to a highly physiologically relevant system for studying human disease. Human organoids reflect key structural and functional properties of organs such as kidney, lung, gut, brain and ... Continued
Spheroid Culture Advancements – Microplates
Spheroid cultures are on the rise as the success of 3D spheroids has been demonstrated in many areas of research including anti-cancer, drug screening, and in vitro tumor studies. With increase in use, has come the need ... Continued
Corning® Nu-Serum™ I/IV Growth Medium Supplements for Reduced-serum Conditions with Fibroblast/Kidney Epithelial Cells
Introduction With the movement towards reduced-serum and serum-free conditions for cell culture, defined formulations and low-protein alternatives are of increasing value. Fetal bovine serum (FBS) is traditionally used as a supplement in media for cell and ... Continued
Cancer Research
Answers by: Corning experts Paula Flaherty, Technology Manager, Jeffrey Partridge, Senior Development Scientist and Hilary Sherman and Audrey Bergeron, Applications Scientists Introduction Unlocking the complexities of cancer is an ongoing challenge. Luckily, a countless number of researchers ... Continued
Enabling Stem Cell Therapy Biomanufacturing using Dissolvable Microcarriers
Introduction Cell culture on microcarriers is an increasingly important technique for the production of large cell quantities and the scale-up of Cell Therapy applications. Microcarriers—small, spherical beads used to grow adherent cells in a suspension culture—offer ... Continued
Going tiny is the next BIG thing: Tools and Techniques for Organoid Cultures
Answers by: Feng Li, Senior Scientist Development, Hilary Sherman, Applications Scientist, Himabindu Nandivada, Senior Development Scientist and Nitin Kulkarni, Sr. Scientific Support Specialist. Introduction In the last decade, organoid cultures have quickly become a popular way to ... Continued
Matrigel – Tips, Tricks and Troubleshooting
We recently finished our Ask the Expert discussion, “Everything you ever wanted to ask about Corning® Matrigel® Matrix”. During this Ask the Expert session, we had a wide range of questions and discussed everything from ... Continued
A Novel 3D Immune Oncology Model for High Throughput Testing of Tumoricidal Capability
Introduction Immunotherapy, particularly for cancer treatment, is a very active area of both academic and clinical research. There has been increased interest in utilizing a patient’s own T cells to attack their tumors. However, positive laboratory ... Continued
Everything you ever wanted to ask about Corning® Matrigel® Matrix
For the past 30 years, Corning Matrigel matrix has been used by researchers across the globe in essential applications through to cutting-edge, life-changing research. The number of citations for Matrigel matrix recently climbed over 10,000 citations and spans applications areas from cancer research to stem cells, and from organoid cultures to neuroscience....Continued
Using the Corning HYPERStack Cell Culture Vessel and the Enhanced Attachment Microcarriers for Scale-Up and Production in the Vaccine Industry
Katherine E. Strathearn, Ph.D., Mansi Soni, and Mark E. Rothenberg, Ph.D. Corning Incorporated Introduction Viral transductions are used at the preclinical and clinical stages in the vaccine industry leading to an increase in demand to produce more ... Continued
Novel ECM Mimetic Surfaces for Cell Expansion and Differentiation
Corning Life Sciences ASCB December 17, 2012 Marshall Kosovsky, Ph.D., Technical Support Manager Continued