Platinum Sponsor
Cytiva (formerly GE)
Cytiva is a global provider of technologies and services that help advance and accelerate the development and manufacture of therapeutics. Previously GE Healthcare Life Sciences, Cytiva’s diverse portfolio includes well-recognized brands such as ÄKTA, Amersham, Biacore, FlexFactory, HyClone, MabSelect, Sefia, Whatman, Xcellerex and Xuri. Cytiva brings speed, efficiency, and capacity to research and manufacturing workflows, enabling the delivery of transformative medicines to patients. Visit cytiva.com for more.
Associated Experts
Job Title: Director
Job Title: Principal Scientist
Job Title: Product Manager WAVE Bioreactor Hardware
Job Title: Senior Scientist
Job Title: Principal Scientist
Job Title: Senior Global Product Manager
Job Title: Customer Applications Director, Life Sciences
Job Title: Senior Manager
Job Title: Director of Process Science
Job Title: General Manager of Cell & Gene Therapy Strategy
Job Title: Executive Account Manager, Technology Lead - T-Cell Applications, Cell Technologies Division
Job Title: Material Science Leader
Associated Content
Xcellerex Automated Perfusion System provides a single-use, automated solution to simplify perfusion production
The Xcellerex APS provides a solution to the challenges of traditional perfusion culture systems by integrating automation and limiting manual operations. The flexibility and scalability of the system further increases its value in providing solutions across several different perfusion applications....Continued
Scaling Strategy for Moving mAb Process from Microscale to Production Scale Bioreactors
The most efficient process optimization requires successful scale-up and scale-down of manufacturing processes. Scaling strategies are key to ensuring that the scaled-down process will scale-up as expected and that the scaled-down process is a true ... Continued
Raw Material Quality – Identifying and Mitigating Variation
In this podcast, we interviewed Cory Card, Principal Scientist Life Sciences, GE Healthcare about raw material quality, its impact on cell culture and technologies to identify and mitigate raw material variation. ...Continued
Semi-automated Closed CAR-T Manufacturing Process
CAR-T cell-based gene therapy technology is one of the most exciting new medical developments, with two of the most popular examples being the cancer immunotherapies Kymriah® and Yescarta®. These cell-based gene therapies have been able to ... Continued
Successful Methods for Perfusion Process Optimization
In this podcast, we interviewed Dr. Andreas Castan, Principal Scientist at GE Healthcare Life Sciences about the best methods for optimizing perfusion processes. This included a discussion of tools for media optimization and innovative cell separation techniques....Continued
A Road Map for Efficient Fed-Batch Cell Culture Optimization
In this podcast and accompanying article, we interviewed Dr. Andreas Castan, Principal Scientist at GE Healthcare Life Sciences about the most efficient ways to optimize fed-batch cell culture production for CHO-based antibodies. This included a discussion of media vs. feed strategies, incorporating critical quality attributes, evaluating the impact of optimizing on downstream processing and more....Continued
Viral Vector Manufacturing for Gene Therapy
In this podcast and accompanying article, we interviewed Dr. Mats Lundgren, PhD Customer Applications Director, Life Sciences, GE Healthcare, Sweden about developing platform processes for viral vector manufacturing and Mats describes a recently developed platform process for adenovirus production. ...Continued
Implementing Digital Biomanufacturing in Process Development
At this year’s Bioprocess International Conference in Boston, Dr. Thomas Seewoester, Amgen gave a very insightful and inspiring keynote presentation titled, “Bioprocessing 4.0 – Digital technologies are transforming biologics manufacturing.” In the talk, he discussed ... Continued
Closed System Cell Therapy Manufacturing – Moving from the lab to clinical and commercial production
Panel discussion on key considerations for moving cell therapies from lab to commercial manufacturing, including the benefits of manufacturing in a closed system. We also discussed what were some of the key hurdles and possible solutions associated with transitioning to clinical and commercial cell therapy manufacturing....Continued
Theranostics: an old approach with new interest
Introduction Precision medicine has been a growing trend in healthcare for years. Doctors and researchers are leveraging computer power, modern analytics, cloud technology and patient information from genomics to demographics to help make more individualized and ... Continued
Fed-batch culture – Optimizing feed strategies now and in the future
Fed-batch culture as a mode of production developed rather gradually and organically. Years ago, engineers noticed that cultures depleted media of the main carbon sources, glucose and glutamine. To extend culture life, they added more of each, initially in a timed schedule but eventually in closed-loop (feed-back) based control. However, concern soon grew regarding concomitant production of the by-products lactate and ammonia having a negative effect on pH and osmolality, and consequently upon cell activity, production and product quality. This led to the development of new approaches for controlling this rational supplementation of glucose and glutamine in a fed-batch approach, and the use of alternative carbon sources....Continued
Implementation of Single-use Bioreactors for Microbial Fermentation is Easier Than You Think
Ken Clapp, a senior member of GE Healthcare Life Sciences' upstream product management team explores in more detail the implementation of single-use systems for microbial fermentation including which processes make good candidates for single-use and considerations for transitioning from stainless steel....Continued
Single-use Bioreactors for Fermentation – It’s now a reality that deserves consideration
Ken Clapp, a senior member of GE Healthcare Life Sciences' upstream product management team discusses the use of single-use bioreactors for fermentation, how single-use technology has evolved to meet the more rigorous demands of fermentation, and the benefits of single-use for this application....Continued
Transcriptome analysis reveals strategies for CHO cell culture media design and feed-spiking strategy to improve batch culture
When looking at batch vs. fed-batch culture, there are advantages and disadvantages to each, so considering the application is very important. Batch cultures are fairly simple, straightforward and take very little time to set up. ... Continued
Development of DoE based fed-batch strategies for high-producing CHO cell cultures
Successful optimization of Chinese hamster ovary (CHO) cell culture for biomanufacturing has a significant impact on productivity, protein quality, manufacturing efficiency and economic feasibility. To achieve the highest performing cell culture, a fed-batch culture strategy ... Continued
Automated, single-use filtration to increase efficiency in upstream and downstream operations
In examining ways to improve overall bioprocess efficiency, filtration is a step that can sometimes be overlooked. However it is a key area to improve efficiency, as it is part of both upstream and downstream ... Continued
Purposeful design of a next-generation single-use film for optimized performance in biomanufacturing
In this mini-webinar, Susan Burke, PhD, Bioprocess R&D, GE Healthcare, Life Sciences, presents the process in which GE Healthcare developed a next-generation single-use platform film, Fortem™. Fortem is available across GE’s entire portfolio of single-use ... Continued
The Importance of Resin Selection in Development of a Platform Bioprocess Film
Utilizing single-use technologies for biomanufacturing is growing due to several operational benefits including; reduced cleaning and validation, decreased water usage, lower initial capital investment, increased manufacturing flexibility, and faster turnaround time between runs. As the implementation ... Continued
A New Chemically-defined Medium for use with Suspension-adapted Avian Cells in Vaccine Manufacturing
Much of current cell-based vaccine manufacturing is done in cell lines like Vero (African green monkey kidney), MDCK (Madin-Darby canine kidney) or CEF (chicken embryo fibroblast) cells. These cell lines are adherent cells that require ... Continued
Single-Use Technology for Microbial Fermentation
Introduction Microbial fermentation processes are used for biomanufacturing of various drugs and vaccines, such as hormones, antibody fragments, and pneumococcal vaccine. Stirred-tank fermentors up to 100,000 L scale have traditionally been used in such microbial processes ... Continued
Raising the bar for rocking bioreactors: Introducing the ReadyToProcess WAVE 25 system
A Guest Blog by Cecilia Annerén PhD, Product Manager WAVE Bioreactor Hardware, GE Healthcare Life Sciences The WAVE Bioreactor™ system was the first single-use bioreactor on the market when it was introduced in the late 1990s. ... Continued
Stir Up Your Culture – Learn How to Succeed with Xcellerex Bioreactor Applications in a Manufacturing Environment
Introduction Xcellerex XDR single-use, stirred-tank bioreactors are well-characterized systems that deliver a performance comparable with that of conventional bioreactors from process development to manufacturing scale. The technology has been successfully used in a variety of different ... Continued
Single-Use Bioreactor Mixing: How to meet familiar requirements with novel technologies
A Guest Blog by: Ken Clapp, Product Manager Bioreactors, Xcellerex, now part of GE Healthcare Life Sciences Eva Lindskog, Upstream Marketing Leader, GE Healthcare Life Sciences Single-use bioreactor mixing: how to meet familiar requirements with novel technologies A critical ... Continued
Catch the WAVE – A discussion on using the WAVE disposable bioreactor for research and manufacturing operations
Introduction An early pioneer in the area of disposable bioreactors, the WAVE Bioreactor was the first single-use bioreactor system when it was presented to the bioprocessing community in 1996. Since then, the range of products has ... Continued
Perfusion culture made easy with WAVE Bioreactor™ 2/10 system
Source: GE Life Sciences Uploaded on Sep 27, 2011 The WAVE Bioreactor™ system from GE Healthcare is a functionally closed system and can be used for various cell culture applications. The video illustrates the workflow for ... Continued